Search results for "Lacrimal gland"
showing 10 items of 13 documents
No consequence of dietary omega-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye
2008
International audience; Purpose:Epidemiological studies suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) may protect against prevalence of dry eye. This work aimed to evaluate whether a dietary deficiency in omega-3 PUFAs may increase the severity of dry eye in a scopolamine-induced rat model. Methods:Three consecutive generations of Lewis rats were bred under diets deprived of omega-3 PUFAs. Dry eye was experimentally induced by continuous scopolamine delivery in female animals from the third deficient generation and in female Lewis rats fed for three generations with a balanced diet. After 14 days of treatment, the clinical signs of ocular dryness were evaluated in vivo us…
Identification of lipid accumulation in lacrimal gland from NOD mice
2008
International audience; Purpose: : The NOD mouse is an established animal model of the human disease, Sjögren’s syndrome. The lacrimal gland of male NOD mouse becomes significantly infiltrated with inflammatory cells by 12 weeks of age. Dacryadenitis is associated with massive lipid deposition in the lacrimal acinar cells, a process which starts by 6 weeks of age and is accompanied by onset of inflammatory infiltrates. The aim of this study was to identify the lipids that accumulate in lacrimal glands from NOD mice. Methods: : Lacrimal glands were excised from 12-week-old male NOD (n = 8) and BALB/c mice (n = 10). Lipids were extracted and lipid class distribution examined. Then the lipid c…
Lipid and fatty acid profile of the retina, RPE/choroid and lacrimal gland, and associations with dietary fatty acids in human subjects
2008
Purpose The contribution of dietary lipids to the accumulation of lipids in the retina during ageing and in the course of age related maculopathies remains under debate. Our objective was to establish associations between fatty acid profiles of ocular structures, and adipose tissue as a surrogate for the past dietary intake of the subjects. Methods Lipids and fatty acids were analyzed by tandem thin-layer chromatography-flame ionization detection and gas chromatography-flame ionization detection from the neural retina, RPE/choroid, lacrimal gland and adipose tissue, collected from 19 women and 8 men, aged 59–95 years. Results DHA concentrations in the neural retina were positively associate…
Adénocarcinome de la glande lacrymale dans un rétinoblastome bilatéral traité avec radiothérapie externe : à propos d’un cas
2011
This clinical case report describes the clinical findings and diagnosis of lacrimal gland adenocarcinoma that developed 20 years after external beam radiotherapy in the treatment of bilateral retinoblastoma. Visual acuity, slit lamp biomicroscopy, fundus color photography, nuclear magnetic resonance, lateral orbitotomy and histological analysis are described.
Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty ac…
2008
International audience; Accumulation of lipids within Bruch’s membrane (BrM) and between BrM and retinal pigment epithelium (RPE) accounts for one of the biological changes associated with normal aging and may contribute to the development of age-related maculopathies. The origin of these lipids is still being actively investigated. The relative contribution of plasma lipids and lipids coming from the neural retina remains a matter of controversy. Low-density lipoproteins (LDLs) have been reported to significantly participate in the retina’s lipid supply, after active remodeling within RPE. Meanwhile, RPE expresses the enzymatic machinery for synthesizing lipoprotein-like particles. The obj…
Computed Tomography in Orbital Lesions
1981
Lesions in the orbits are characterized by unilateral or bilateral proptosis and/or disorders of ocular motion. Before the advent of computed tomography diagnosis was made on the basis of conventional radiological studies of the skull and the orbits as well as with ultrasonog-raphy, fluorescence angiography, phlebography of the ophthalmic vein, and arteriograms of the internal and external carotid arteries. The introduction of CT has brought about a correspondingdecline in the use of invasive procedures (Wende et al. 1977).
Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorp…
2007
International audience; The purpose of this study was to compare the susceptibility of the retina and the exorbital lacrimal gland to dietary supplies of long-chain omega-3 (omega 3) and omega-6 (omega 6) polyunsaturated fatty acids (LC-PUFAs). Male Wistar rats were fed a 5% lipid diet containing: (1) 10% eicosapentaenoic acid (EPA) and 7% docosahexaenoic acid (DHA), or (2) 10% gamma-linolenic acid (GLA), or (3) 10% EPA, 7% DHA and 10% GLA or (4) a balanced diet deprived of EPA, DHA and GLA for 3 months. Lipids were extracted from plasma phospholipids, retina and exorbital lacrimal gland, and fatty acid composition was determined by gas chromatography. Dietary supplementation with EPA and D…
CT and MR Imaging of Orbital Lesions
1989
In the past, the diagnosis of orbital lesions manifested clinically by unilateral or bilateral proptosis and/or impaired ocular motility has relied on conventional skull films and orbital radiographs, sonography, fluorescein angiography, internal and external carotid angiography, and ophthalmic venography. The introduction of CT, however, has greatly reduced the importance of invasive diagnostic procedures (Wende et al. 1977).
Changes in Tear Protein Pattern after Photorefractive Keratectomy
2003
PURPOSE. Changes in tear protein composition of patients who underwent photorefractive keratectomy (PRK) were analyzed. METHODS. Tear samples were obtained from 23 eyes of 23 patients immediately before PRK and on the fourth postoperative day with glass capillaries. Tear proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Digital image analysis and evaluation of the densitometric data of the electrophoretic separations were done with BioDoc-Analyze. RESULTS. Analysis of discriminance found a significant difference in the protein patterns (p<0.001). This type of analysis of the electrophoretic densitographs uses all peak information simultaneously. A signifi…
Proteomics of tear fluid in thyroid-associated orbitopathy.
2012
Proteomics and mass spectrometry are useful tools for peptide screening in body fluids. In thyroid-associated orbitopathy (TAO), evidence for lacrimal gland involvement with altered composition of tears has been reported. Our objective was to detect and evaluate potential changes in the proteomic patterns of tear fluid in TAO.Tear fluid was collected from 45 patients with TAO and 15 healthy controls. Tear proteins were analyzed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, and peptides were identified using matrix-assisted laser desorption/ionization time-of-flight technology.Peptides with molecular weights 3808 Dalton (Da, p=0.004), 3734 Da (p=0.034),…